DNA methyltransferase inhibitor dramatically alters the secondary metabolism of Pestalotiopsis microspora
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چکیده
منابع مشابه
Distinct Roles of Velvet Complex in the Development, Stress Tolerance, and Secondary Metabolism in Pestalotiopsis microspora, a Taxol Producer
The velvet family proteins have been shown to play critical roles in fungal secondary metabolism and development. However, variations of the roles have been observed in different fungi. We report here the observation on the role of three velvet complex components VeA, VelB, and LaeA in Pestalotiopsis microspora, a formerly reported taxol-producing fungus. Deletion of individual members led to t...
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A new α-pyrone derivative 1, along with four known congeners 2, 3, 4 and 5, were isolated from the solid-substrate fermentation medium of the endophytic fungus Pestalotiopsis microspore isolated from the branch of Taxus chinensis. Their structures and relative configurations were elucidated by extensive spectroscopic analysis. The cytotoxic activities of the isolated α-pyrone derivatives agains...
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The canonical Gcn2/Cpc1 kinase in fungi coordinates the expression of target genes in response to amino acid starvation. To investigate its possible role in secondary metabolism, we characterized a gcn2 homolog in the taxol-producing fungus Pestalotiopsis microspora. Deletion of the gene led to severe physiological defects under amino acid starvation, suggesting a conserved function of gcn2 in ...
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Primary cilia are sensory organelles present on most differentiated cells. Their assembly or function is impaired in several human diseases, including polycystic kidney disease (PKD). However, the mechanism by which ciliary dysfunction contributes to these pathologies is incompletely understood. PKD is characterized by altered transepithelial fluid transport, due to the mislocalization of ion p...
متن کاملThe AMP-Activated Protein Kinase Homolog Snf1 Concerts Carbon Utilization, Conidia Production and the Biosynthesis of Secondary Metabolites in the Taxol-Producer Pestalotiopsis microspora
Highly conserved, the Snf1/AMPK is a central regulator of carbon metabolism and energy production in the eukaryotes. However, its function in filamentous fungi has not been well established. In this study, we reported functional characterization of Snf1/AMPK in the growth, development and secondary metabolism in the filamentous fungus Pestalotiopsis microspora. By deletion of the yeast SNF1 hom...
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ژورنال
عنوان ژورنال: Journal of Chinese Pharmaceutical Sciences
سال: 2017
ISSN: 1003-1057
DOI: 10.5246/jcps.2017.05.037